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Washington University Digestive Diseases Research Core Center

The overarching mission of the Washington University Digestive Disease Research Core Center (DDRCC) is to advance research in digestive disease with a focus on interactions between host and environment. The WU-DDRCC seeks to advance the health of patients with digestive diseases by supporting enabling technology and promoting the basic and translational research interests of its 48 Full + 25 Associate members. 

Our Mission

The overarching mission of this center is to advance research in digestive disease with a focus on interactions between host and environment.  The WU-DDRCC seeks to advance the health of patients with digestive diseases by supporting enabling technology and promoting the basic and translational research interests of its 48 FULL + 25 ASSOCIATE members.  These interests are organized around three major themes, including: (1) Host-microbial interactions, inflammation and mucosal immunity; (2) Stem cells, development, epithelial renewal, and cancer biology; (3) Nutrient transport, metabolism and signaling.

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Our Central Hypothesis is that advances across the spectrum of clinical care of patients with digestive diseases requires a community of basic and translational investigators to advance understanding of disease pathways and mechanisms, to promote scientific collaboration and synergies and ultimately to identify new therapeutic opportunities with the potential for rapid translation into clinical trials.

This Central Hypothesis will be pursued through the following SPECIFIC AIMS:

  1. Provide a responsive Administrative core that promotes collaborative and synergistic interactions between investigators from multiple disciplines engaged in digestive disease related research with a focus on interactions between host and environment.
  2. Organize and support Core laboratories and services that provide state-of-the-art services and specialized expertise that would otherwise not be available to individual investigators, in a cost-effective manner.
  3. Provide a scientific Enrichment program sponsoring visiting researchers and workshops to augment the scientific milieu, promote collaboration and stimulate development of new initiatives in digestive disease.
  4. Support a professional academic training program that promotes the interests and development of graduate students, postdoctoral trainees, housestaff, fellows and junior faculty as well as allied health professionals to pursue careers in digestive disease research.
  5. Identify, support and nurture new investigators interested in digestive disease research through an annual Pilot and Feasibility awards program.
  6. Promote and share technology development with other DDRCCs regionally and nationally.

The four cores are designed to facilitate analysis of the regulatory factors in the GI tract both in vivo and in vitro and to correlate structure with function. The Administrative Core oversees the operation of the DDRCC and administers the Pilot and Feasibility Program to foster participation by younger, and established, investigators in digestive diseases-related research. In addition, the NIH-sponsored General Clinical Research Center at Washington University provides DDRCC members with resources for conducting clinical research. Several DDRCC members who are experts in translational GI research are utilizing the GCRC. 

  • Administrative and Resource Access Core
  • Advanced Imaging & Tissue Analysis Core
  • Biobank Core
  • Murine Models & Gnotobiotics Core

Cindy Martinez
http://ddrcc.wustl.edu/
DDRCC Administrator
Internal Medicine – Gastroenterology
660 S. Euclid, Campus Box 8124
St. Louis, MO 63110
Phone: (314)362-0799
Fax: (314)362-2505