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USC Liver Transplant Program and Center for Liver Disease

USC Research Center for Liver Diseases (RCLD) has been supported by NIDDK since its inception in 1995 and is currently in it’s 5th 5-year cycle of funding (2016-2021). Its overarching vision is to provide a home and an organized central focus and mechanism for achievement of its goal for intellectual and creative interplay between basic and clinical investigations.

Our Mission

RCLD has the principal goal of fostering-facilitating interdisciplinary and collaborative research in liver diseases with a growing translational emphasis that fit scientifically into the research Themes of the Center (see Research Focus). In addition, our overarching vision is to provide a “home” and organized central focus through the Center mechanism for the achievement of this goal for the intellectual and creative interplay between basic and clinical investigations. The achievement of this goal and vision is through provision of needed Core facilities and services, which provide widely utilized routine, as well as highly specialized technologies, funding of innovative Pilot/Feasibility (P/F) projects, which preferentially enhance career development of young investigators, and an Enrichment Program through regular seminars plus an Annual Symposium for exchange of ideas, intellectual interactions and stimulation of collaboration.

A key goal of the Center is to attract the participation of young investigators in digestive diseases and established investigators in other disciplines and to promote the career development of young investigators making the transition to independence. Interdisciplinary participation is crucial in carrying out this plan and we have the enthusiastic participation of Center members from nearly every Department, but mainly Medicine, Biochemistry & Molecular Biology, Cell Biology, Gerontology, Microbiology & Immunology, Pathology, Pediatrics, Pharmacology & Pharmaceutical Sciences, and Surgery.

In summary, the key goal of the Center is the facilitation (Cores) and fostering (Cores, P/F projects, Enrichment Program) of interdisciplinary collaborative research to lead to a better understanding of the pathobiology of diseases of the liver and digestive tract and the development of new treatments for these diseases.

The Center serves as a focal point for faculty from throughout the University who join together with shared interests in Liver Diseases and other aspects of Digestive Diseases which are of common interest in Themes and subthemes, referred to as special interest groups (SIGs). The designation of SIG identifies groups of investigators who interact regularly, cross-collaborate extensively and share methods and resources.

The Center’s membership and activities have led to thematic organization of a Research Base devoted to Liver Disease with the following four major Themes:

  • Viral hepatitis and hepatocellular carcinoma
  • Steatohepatitis and fibrosis
  • Liver injury (hepatotoxicity and mitochondrial pathobiology)
  • Repair, regenerative medicine, and developmental biology

 

 

The following sites provide access to the information regarding each RCLD investigator.

Research Themes and Base and Special Interest Groups (SIGs):
http://keck.usc.edu/liver-diseases-research-center/courses/research-them…

Membership Roster:
http://keck.usc.edu/liverdiseasesresearchcenter/wp-content/uploads/sites…

Keck faculty website for alphabetical access to each faculty’s webpage:
http://keck.usc.edu/faculty-search/