Stem cell niches: famished paneth cells, gluttonous stem cells.

Publication Type:

Journal Article


Current biology : CB, Volume 22, Issue 14, p.R579-80 (2012)


Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.