Featured Articles

Microbial exposure during early life has persistent effects on natural killer T cell function.
Dynamic migration of γδ intraepithelial lymphocytes requires occludin.
Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR
Proceedings of the National Academy of Sciences of the United States of America, 2012 May 1, Volume 109, Issue 18, p.7097-102, (2012)
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NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.
Franchi L, Kamada N, Nakamura Y, Burberry A, Kuffa P, Suzuki S, Shaw MH, Kim Y-G, Núñez G
Nature immunology, 2012 May, Volume 13, Issue 5, p.449-56, (2012)
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Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS
Science (New York, N.Y.), 2012 Apr 27, Volume 336, Issue 6080, p.489-93, (2012)
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Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.
Kanda M, Matthaei H, Wu J, Hong S-M, Yu J, Borges M, Hruban RH, Maitra A, Kinzler K, Vogelstein B, Goggins M
Gastroenterology, 2012 Apr, Volume 142, Issue 4, p.730-733.e9, (2012)
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The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.
Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, et al.
Cell, 2012 Mar 30, Volume 149, Issue 1, p.146-58, (2012)
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TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases.
Lee J, Moir RD, McIntosh KB, Willis IM
Molecular cell, 2012 Mar 30, Volume 45, Issue 6, p.836-43, (2012)
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Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Hadeiba H, Lahl K, Edalati A, Oderup C, Habtezion A, Pachynski R, Nguyen L, Ghodsi A, Adler S, Butcher EC
Immunity, 2012 Mar 23, Volume 36, Issue 3, p.438-50, (2012)
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Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
Kwon H-S, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M
Journal of immunology (Baltimore, Md. : 1950), 2012 Mar 15, Volume 188, Issue 6, p.2712-21, (2012)
Pubmed

The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras.
Gus-Brautbar Y, Johnson D, Zhang L, Sun H, Wang P, Zhang S, Zhang L, Chen YH
Molecular cell, 2012 Mar 9, Volume 45, Issue 5, p.610-8, (2012)
Pubmed

Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL
Journal of immunology (Baltimore, Md. : 1950), 2012 Mar 1, Volume 188, Issue 5, p.2065-9, (2012)
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Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages.
Ochsenbauer C, Edmonds TG, Ding H, Keele BF, Decker J, Salazar MG, Salazar-Gonzalez JF, Shattock R, Haynes BF, Shaw GM, Hahn BH, Kappes JC
Journal of virology, 2012 Mar, Volume 86, Issue 5, p.2715-28, (2012)
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Evolutionarily assembled cis-regulatory module at a human ciliopathy locus.
Lee JH, Silhavy JL, Lee JE, Al-Gazali L, Thomas S, Davis EE, Bielas SL, Hill KJ, Iannicelli M, Brancati F, Gabriel SB, Russ C, Logan CV, Sharif SM, Bennett CP, et al.
Science (New York, N.Y.), 2012 Feb 24, Volume 335, Issue 6071, p.966-9, (2012)
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NHERF-2 maintains endothelial homeostasis.
Bhattacharya R, Wang E, Dutta SK, Vohra PK, E G, Prakash YS, Mukhopadhyay D
Blood, 2012 Feb 17, (2012)
Pubmed

Origins of tumor-associated macrophages and neutrophils.
Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJH, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo J-L, Chen JW, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012 Feb 14, Volume 109, Issue 7, p.2491-6, (2012)
Pubmed

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez J-P, Shulman GI, Gordon JI, Hoffman HM, Flavell RA
Nature, 2012 Feb 9, Volume 482, Issue 7384, p.179-85, (2012)
Pubmed

Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.
Xia D, Wang D, Kim S-H, Katoh H, DuBois RN
Nature medicine, 2012 Feb, Volume 18, Issue 2, p.224-6, (2012)
Pubmed

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.
Patel RM, Myers LS, Kurundkar AR, Maheshwari A, Nusrat A, Lin PW
The American journal of pathology, 2012 Feb, Volume 180, Issue 2, p.626-35, (2012)
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AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.
Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M
Nature immunology, 2012 Feb, Volume 13, Issue 2, p.144-51, (2012)
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Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling.
Sun X, Threadgill D, Jobin C
Gastroenterology, 2012 Jan, Volume 142, Issue 1, p.86-95.e5, (2012)
Pubmed

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Hu L, Crawford SE, Czako R, Cortes-Penfield NW, Smith DF, Le Pendu J, Estes MK, Prasad VBV
Nature, 2012, Volume 485, Issue 7397, p.256-9, (2012)
Pubmed

NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.
Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RMB, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL
Nature medicine, 2012, Volume 18, Issue 4, p.555-63, (2012)
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