Mucosal HIV and Immunobiology CenterVisit this Center

The Mucosal HIV and Immunobiology Center at the University of Alabama at Birmingham was established through the Digestive Diseases Research Development Center program of the National Institutes of Health (NIDDK). The initial application for the Center was a collaborative effort by the Departments of Medicine, Pathology, and Microbiology; the Comprehensive Cancer Center and Center for AIDS Research; and the University of Alabama Health Services Foundation's General Endowment Fund for the Interdisciplinary Program in Mucosal Immunology. The Center is in the Department of Medicine, which currently ranks seventh nationally among departments of medicine in NIH support.

Our Mission

The mission of the Mucosal HIV and Immunobiology Center is to (a) synergize UAB investigators into a highly cohesive research force with enhanced capabilities to conduct pioneering research into the interaction between microbes and host mucosal cells and (b) stimulate new investigators to study mucosal immune responses to gut microorganisms. The unifying theme for this mission is the interaction between microbes, especially HIV-1, H. pylori and commensal bacteria, and mucosal innate and adaptive immune cells to elucidate disease pathogenesis. Reflecting this theme, the Base Grant portfolio falls into three groups: (1) Mucosal HIV-1 pathogenesis; (2) Helicobacter infection pathogenesis; and (3) Regulation of immune and inflammatory responses to commensal bacteria. Center members study the interaction between these microbes and the relevant mucosal cells, including epithelial cells and lamina propria lymphocytes, macrophages and dendritic cells, using primary human and murine cells, explant models and mouse models. The overarching Center goal is to generate new concepts in mucosal microbe immunobiology for the development of novel therapeutic and vaccine strategies.