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University of Chicago Chicago, Illinois

The University of Chicago DDRCC is committed to building a better understanding of gastrointestinal diseases by fostering research, collaboration, and new technology.

Our Mission
The University of Chicago Digestive Disease Research Core Center (DDRCC) is committed to building a better understanding of gastrointestinal diseases like inflammatory bowel diseases (IBD) and related inflammatory diseases of the bowel by fostering research, collaboration, and new technology and by providing education and resources to talented young investigators in the field of digestive disease research. We offer state of the art services through five core facilities including: the Integrated Translational Research Core, the Host-Microbe Core, the Tissue Engineering and Cell Models Core, the Tissue and Cell Analysis Core and the Administrative Core. The DDRCC continuously evolves to meet the needs of investigators and to anticipate new trends and technologies in biomedical research.

At the University of Chicago DDRCC, we are at the forefront of research in three fields, led by well-known investigators: Dr. Bana Jabri in Celiac disease, Dr. Cathryn Nagler in food allergy and Dr. Eugene B. Chang in inflammatory bowel diseases. The central hypothesis of the collective group is that IBD and related inflammatory diseases of the bowel arise from a confluence of host, microbial, immunological, and environmental factors. Within the field of IBD, the program has 4 major interrelated research themes that focus on the etiopathogenesis of IBD: (1) host immune/tissue responses, (2) the gut microbiome, (3) host genetics and gene function, and (4) environmental modifiers.

Integrated Translational Research (ITR) Core
Provides a bridge between the clinical and basic sciences. Acquires and maintains a collection of IBD clinical metadata and biospecimens.

Tissue Engineering and Cell Models (TECM) Core
Providing novel and traditional experimental model systems that enable and meet the needs of DDRCC investigators.

Tissue and Cell Analysis (TCA) Core
Facilitates the study of intestinal disease by providing surgical and archival tissues and advanced imaging capabilities.

Host-Microbe (HM) Core
Provides advanced facilities, services, and expertise to study of host-microbial interaction relating to human health and inflammatory bowel diseases.

Computational Analysis and Modeling Resource (CAMR) Resource
A component of the Administrative core, the CAMR provides DDRCC users biostatistics, bioinformatics, and computational modeling and simulations to aid in the analysis of big data.

Administrative Core
Eugene B. Chang, M.D.
Bana Jabri, M.D., Ph.D.
John Alverdy, M.D.
Cathryn Nagler, Ph.D.
Joeli Brinkman, Ph.D.


Integrated Translational Research Core
Bana Jabri, M.D., Ph.D.
Joel Pekow, M.D.


Tissue Engineering and Cell Models Core
Eugene B. Chang, M.D.
John Alverdy, M.D.


Host-Microbe Core
Alexander Chervonsky, M.D., Ph.D.
Betty Theriault, DVM
Dionysios Antonopoulos, Ph.D.


Tissue and Cell Analysis Core
Christopher Weber, MD. Ph.D.
Vytautas Bindokas, Ph.D.

Contact Information
5841 S. Maryland Ave., MC 4076
Chicago, IL 60637
Phone: 773-702-6458
http://www.uchicagoddrcc.org/

Twitter: @UChicago_DDRCC
Facebook https://www.facebook.com/UniversityofChicagoDDRCC