Digestive Diseases Centers
MEET THE INVESTIGATORS
Ramnik Xavier, M.D., Ph.D.
Program Director, Center for Inflammatory Bowel Disease
Massachusetts General Hospital/Harvard Medical School
Research Interests: Research Interests: Systems approaches to innate and adaptive immunity
Ramnik Xavier, M.D., Ph.D.
Program Director, Center for Inflammatory Bowel Disease
Massachusetts General Hospital/Harvard Medical School
Research Interests: Research Interests: Systems approaches to innate and adaptive immunity
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Eugene B. Chang, M.D.
Martin Boyer Professor of Medicine
DDRCC Director and Host-Microbe Core Director
University of Chicago
Research Interests: Host-microbial interactions, particularly as they relate to health, digestive diseases and other immune- and metabolic-related disorders
Eugene B. Chang, M.D.
Martin Boyer Professor of Medicine
DDRCC Director and Host-Microbe Core Director
University of Chicago
Research Interests: Host-microbial interactions, particularly as they relate to health, digestive diseases and other immune- and metabolic-related disorders
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Jorge A. Bezerra, M.D.
Director, Cincinnati Digestive Health Center
Cincinnati Children's Hospital
Research Interests: Liver development, regeneration, and repair; molecular basis of biliary atresia; genetic basis of intrahepatic cholestasis
Jorge A. Bezerra, M.D.
Director, Cincinnati Digestive Health Center
Cincinnati Children's Hospital
Research Interests: Liver development, regeneration, and repair; molecular basis of biliary atresia; genetic basis of intrahepatic cholestasis
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Enrique Rozengurt, D.V.M., Ph.D.
Director
CURE: Digestive Diseases Research Centers
Research Interests: Signal transduction pathways in the action of gastrointestinal peptides, bioactive lipids and growth factors in normal and cancerous cells of the digestive system
Enrique Rozengurt, D.V.M., Ph.D.
Director
CURE: Digestive Diseases Research Centers
Research Interests: Signal transduction pathways in the action of gastrointestinal peptides, bioactive lipids and growth factors in normal and cancerous cells of the digestive system
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David A. Shafritz, M.D.
Director, Marion Bessin Liver Research Center
Albert Einstein College of Medicine of Yeshiva University, New York
Research Interests: Liver gene regulation, growth control, and liver repopulation
David A. Shafritz, M.D.
Director, Marion Bessin Liver Research Center
Albert Einstein College of Medicine of Yeshiva University, New York
Research Interests: Liver gene regulation, growth control, and liver repopulation
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Hans-Christian Reinecker, M.D.
Director,Genetics, Genomics and Molecular Biology Core
Massachusetts General Hospital/Harvard Medical School
Research Interests: Mucosal immunity, innate immune defenses, dendritic cell function and intestinal microbiome
Hans-Christian Reinecker, M.D.
Director,Genetics, Genomics and Molecular Biology Core
Massachusetts General Hospital/Harvard Medical School
Research Interests: Mucosal immunity, innate immune defenses, dendritic cell function and intestinal microbiome
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Charles A Parkos, M.D., Ph.D.
Director, Division of Digestive Diseases
Emory University School of Medicine
Research Interests: Pathobiology of leukocyte interactions with mucosal epithelia
Charles A Parkos, M.D., Ph.D.
Director, Division of Digestive Diseases
Emory University School of Medicine
Research Interests: Pathobiology of leukocyte interactions with mucosal epithelia
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Wayne I. Lencer, M.D.
Co-Director HDDC, Professor of Pediatrics,
Childrens Hospital Boston, Harvard Medical School
Research Interests: mechanisms for how intestinal epithelial cells interact with theluminal and sub-epithelial microenvironment, and the cell biology of bacterial pathogenesis and mucosal host defense
Wayne I. Lencer, M.D.
Co-Director HDDC, Professor of Pediatrics,
Childrens Hospital Boston, Harvard Medical School
Research Interests: mechanisms for how intestinal epithelial cells interact with theluminal and sub-epithelial microenvironment, and the cell biology of bacterial pathogenesis and mucosal host defense
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Mark Donowitz, M.D.
Director,
Hopkins Digestive Diseases Basic and Translational Research Core Center
Research Interests: All diseases of the liver; general gastroenterology
Mark Donowitz, M.D.
Director,
Hopkins Digestive Diseases Basic and Translational Research Core Center
Research Interests: All diseases of the liver; general gastroenterology
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Nicholas F. LaRusso, M.D.
Director, Center for Cell Signaling in Gastroenterology
Mayo Clinic
Research Interests: Hepatic epithelial cell function and dysfunction
Nicholas F. LaRusso, M.D.
Director, Center for Cell Signaling in Gastroenterology
Mayo Clinic
Research Interests: Hepatic epithelial cell function and dysfunction
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Chung Owyang, M.D.
Director, Digestive Health Center
Director, In Vivo Studies Core
University of Michigan
Research Interests: Neurohormonal control of digestive functions including pancreatic endocrine and exocrine secretion, GI motility, and eating behavior
Chung Owyang, M.D.
Director, Digestive Health Center
Director, In Vivo Studies Core
University of Michigan
Research Interests: Neurohormonal control of digestive functions including pancreatic endocrine and exocrine secretion, GI motility, and eating behavior
MEET THE INVESTIGATORS
Anil K. Rustgi, M.D.
Director, Center for Molecular Studies in Digestive and Liver Diseases
University of Pennsylvania, School of Medicine
Research Interests: Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI)
Anil K. Rustgi, M.D.
Director, Center for Molecular Studies in Digestive and Liver Diseases
University of Pennsylvania, School of Medicine
Research Interests: Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI)
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Harry B Greenberg, M.D.
Director, Digestive Disease Center
Stanford School of Medicine
Research Interests: Pathogenic viruses that infect the GI tract and liver
Harry B Greenberg, M.D.
Director, Digestive Disease Center
Stanford School of Medicine
Research Interests: Pathogenic viruses that infect the GI tract and liver
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Mary K. Estes, Ph.D.
Director, Texas Medical Center Digestive Diseases Center
Baylor College of Medicine
Research Interests: Viral diarrhea, Norwalk virus, rotavirus and mucosal immunity, translational biology and molecular medicine
Mary K. Estes, Ph.D.
Director, Texas Medical Center Digestive Diseases Center
Baylor College of Medicine
Research Interests: Viral diarrhea, Norwalk virus, rotavirus and mucosal immunity, translational biology and molecular medicine
MEET THE INVESTIGATORS
Lars Eckmann, M.D.
Director, Digestive Disease Research Development Center
University of California, San Diego
Research Interests: Infections of the intestinal tract with microbial pathogens and inflammatory bowel disease
Lars Eckmann, M.D.
Director, Digestive Disease Research Development Center
University of California, San Diego
Research Interests: Infections of the intestinal tract with microbial pathogens and inflammatory bowel disease
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Phillip D. Smith, M.D.
Director, Mucosal HIV and Immunobiology Center
University of Alabama
Research Interests: Mucosal immune responses to enteric pathogens or pathogens acquired via mucosal surfaces, including HIV-1, H. pylori and cytomegalovirus (CMV)
Phillip D. Smith, M.D.
Director, Mucosal HIV and Immunobiology Center
University of Alabama
Research Interests: Mucosal immune responses to enteric pathogens or pathogens acquired via mucosal surfaces, including HIV-1, H. pylori and cytomegalovirus (CMV)
MEET THE INVESTIGATORS
Jacquelyn J. Maher, M.D.
Director, UCSF Liver Center
Research Interests: Clinically relevant diseases such as drug-induced liver injury and nonalcoholic steatohepatitis (NASH)
Jacquelyn J. Maher, M.D.
Director, UCSF Liver Center
Research Interests: Clinically relevant diseases such as drug-induced liver injury and nonalcoholic steatohepatitis (NASH)
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Robert Sandler, M.D., M.P.H.
Director, Center for Gastrointestinal Biology and Disease
UNC
Research Interests: Colon cancer etiology, screening and prevention
Robert Sandler, M.D., M.P.H.
Director, Center for Gastrointestinal Biology and Disease
UNC
Research Interests: Colon cancer etiology, screening and prevention
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Neil Kaplowitz, M.D.
Director, USC Liver Transplant program and Center for Liver Disease
USC, Los Angeles
Research Interests: Drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, ER stress, mitochondrial biogenesis
Neil Kaplowitz, M.D.
Director, USC Liver Transplant program and Center for Liver Disease
USC, Los Angeles
Research Interests: Drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, ER stress, mitochondrial biogenesis
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Richard M. Peek, Jr., M.D.
Director, Digestive Disease Research Center
Vanderbilt University
Research Interests: Pathogenesis of Helicobacter pylori infection and gastric cancer
Richard M. Peek, Jr., M.D.
Director, Digestive Disease Research Center
Vanderbilt University
Research Interests: Pathogenesis of Helicobacter pylori infection and gastric cancer
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Nicholas Davidson, M.D.
Director, Division of Gastroenterology
Washington University
Research Interests: Complex lipid trafficking from cells of the small intestine and liver
Nicholas Davidson, M.D.
Director, Division of Gastroenterology
Washington University
Research Interests: Complex lipid trafficking from cells of the small intestine and liver
MEET THE INVESTIGATORS
Michael H Nathanson, M.D., Ph.D.
Director, Yale Liver Center
Research Interests: Mechanisms and effects of calcium signals in polarized epithelia; effect of spatial organization of calcium signals on organ function regulation; factors that organize Ca2+ waves in hepatocytes; organization and effects of Ca2+ waves in cholangiocytes; mechanisms and effects of Ca2+ signals in the nucleus
Michael H Nathanson, M.D., Ph.D.
Director, Yale Liver Center
Research Interests: Mechanisms and effects of calcium signals in polarized epithelia; effect of spatial organization of calcium signals on organ function regulation; factors that organize Ca2+ waves in hepatocytes; organization and effects of Ca2+ waves in cholangiocytes; mechanisms and effects of Ca2+ signals in the nucleus
