Virion assembly and release.

Publication Type:

Journal Article

Source:

Current topics in microbiology and immunology, Volume 369, p.199-218 (2013)

Keywords:

Animalsdigestive disease, digestive deseases Hepacivirusdigestive disease, digestive deseases Hepatitis Cdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Viral Proteinsdigestive disease, digestive deseases Viriondigestive disease, digestive deseases Virus Assemblydigestive disease, digestive deseases Virus Shedding

Abstract:

Hepatitis C Virus (HCV) particles exhibit several unusual properties that are not found in other enveloped RNA viruses, most notably their low buoyant density and interaction with serum lipoproteins. With the advent of systems to grow HCV in cell culture, the molecular basis of HCV particle assembly and release can now be addressed. The process of virus assembly involves protein-protein interactions between viral structural and nonstructural proteins and the coordinated action of host factors. This chapter reviews our current understanding of these interactions and factors.