Regulation of pol III transcription by nutrient and stress signaling pathways.

Publication Type:

Journal Article

Source:

Biochimica et biophysica acta, Volume 1829, Issue 3-4, p.361-75 (2013)

Keywords:

Animalsdigestive disease, digestive deseases DNA-Directed RNA Polymerasesdigestive disease, digestive deseases Fooddigestive disease, digestive deseases Gene Expression Regulationdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Repressor Proteinsdigestive disease, digestive deseases Signal Transductiondigestive disease, digestive deseases Stress, Physiologicaldigestive disease, digestive deseases Transcription Factors, TFIIIdigestive disease, digestive deseases Transcription, Geneticdigestive disease, digestive deseases Yeasts

Abstract:

Transcription by RNA polymerase III (pol III) is responsible for ~15% of total cellular transcription through the generation of small structured RNAs such as tRNA and 5S RNA. The coordinate synthesis of these molecules with ribosomal protein mRNAs and rRNA couples the production of ribosomes and their tRNA substrates and balances protein synthetic capacity with the growth requirements of the cell. Ribosome biogenesis in general and pol III transcription in particular is known to be regulated by nutrient availability, cell stress and cell cycle stage and is perturbed in pathological states. High throughput proteomic studies have catalogued modifications to pol III subunits, assembly, initiation and accessory factors but most of these modifications have yet to be linked to functional consequences. Here we review our current understanding of the major points of regulation in the pol III transcription apparatus, the targets of regulation and the signaling pathways known to regulate their function. This article is part of a Special Issue entitled: Transcription by Odd Pols.