Progression of β-cell dysfunction in obese youth.

Publication Type:

Journal Article


Current diabetes reports, Volume 13, Issue 1, p.89-95 (2013)


Adolescentdigestive disease, digestive deseases Diabetes Mellitus, Type 2digestive disease, digestive deseases Disease Progressiondigestive disease, digestive deseases Glucose Intolerancedigestive disease, digestive deseases Humansdigestive disease, digestive deseases Insulin Resistancedigestive disease, digestive deseases Insulin-Secreting Cellsdigestive disease, digestive deseases Obesity


The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related complications, will present a considerable burden for young adults and a strain on public health. Therefore, it is important to understand the pathophysiology of early phases of disruption of glucose tolerance and identify those critical points in which diabetes may be prevented. β-Cell dysfunction has been shown to represent one of the key pathogenetic defects underlying the progression to diabetes in obese youth. In the present review, we describe longitudinal and cross-sectional studies of changes in insulin sensitivity and secretion across the spectrum of glucose tolerance in obese adolescents. Further, the role of ectopic fat accumulation is discussed in relation to its association with both β-cell dysfunction and insulin resistance.