Molecular mechanisms driving respiratory syncytial virus assembly.

Publication Type:

Journal Article

Source:

Future microbiology, Volume 8, Issue 1, p.123-31 (2013)

Keywords:

Animalsdigestive disease, digestive deseases Cell Membranedigestive disease, digestive deseases Cytoskeletondigestive disease, digestive deseases Host-Pathogen Interactionsdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Protein Transportdigestive disease, digestive deseases Respiratory Syncytial Virusesdigestive disease, digestive deseases Ribonucleoproteinsdigestive disease, digestive deseases Viral Fusion Proteinsdigestive disease, digestive deseases Viral Proteinsdigestive disease, digestive deseases Virus Assemblydigestive disease, digestive deseases Virus Release

Abstract:

Respiratory syncytial virus is a single-stranded RNA virus in the Paramyxoviridae family that preferentially assembles and buds from the apical surface of polarized epithelial cells, forming filamentous structures that contain both viral proteins and the genomic RNA. Recent studies have described both viral and host factors that are involved in ribonucleoprotein assembly and trafficking of viral proteins to the cell surface. At the cell surface, viral proteins assemble into filaments that probably require interactions between viral proteins, host proteins and the cell membrane. Finally, a membrane scission event must occur to release the free virion. This article will review the recent literature describing the mechanisms that drive respiratory syncytial virus assembly and budding.