miRNAs as modulators of angiogenesis.

Publication Type:

Journal Article

Source:

Cold Spring Harbor perspectives in medicine, Volume 3, Issue 2, p.a006643 (2013)

Keywords:

Animalsdigestive disease, digestive deseases Apoptosisdigestive disease, digestive deseases Endothelial Cellsdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Micedigestive disease, digestive deseases MicroRNAsdigestive disease, digestive deseases Molecular Targeted Therapydigestive disease, digestive deseases Neoplasmsdigestive disease, digestive deseases Ribonuclease IIIdigestive disease, digestive deseases Up-Regulationdigestive disease, digestive deseases Vascular Endothelial Growth Factor A

Abstract:

MicroRNAs are highly expressed in endothelial cells, and recent data suggest that they regulate aspects of vascular development and angiogenesis. This study highlights the state of the art in this field and potential therapeutic opportunities. MicroRNAs (miRNAs) represent a family of conserved short (≈22 nt) noncoding single-stranded RNAs that have been identified in plants and animals. They are generated by the sequential processing of the RNA template by the enzymes Drosha and Dicer, and mature miRNAs can regulate the levels of gene expression at the posttranscriptional level. miRNAs participate in a diverse range of regulatory events via regulation of genes involved in the control of processes such as development, differentiation, homeostasis, metabolism, growth, proliferation, and apoptosis. However, rather than functioning as regulatory on-off switches, miRNAs often function to modulate or fine-tune cellular phenotypes. So far, more than 1000 mammalian miRNAs have been identified since the discovery of the first two miRNAs (lin-4 and let-7), and bioinformatics predictions indicate that mammalian miRNAs can regulate ∼30% of all protein-coding genes.