Human hemato-lymphoid system mice: current use and future potential for medicine.

Publication Type:

Journal Article

Source:

Annual review of immunology, Volume 31, p.635-74 (2013)

Keywords:

Animalsdigestive disease, digestive deseases Hematopoiesisdigestive disease, digestive deseases Hematopoietic Stem Cell Transplantationdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Immunophenotypingdigestive disease, digestive deseases Lymphoid Tissuedigestive disease, digestive deseases Micedigestive disease, digestive deseases Models, Animaldigestive disease, digestive deseases Translational Medical Researchdigestive disease, digestive deseases Transplantation, Heterologous

Abstract:

To directly study complex human hemato-lymphoid system physiology and respective system-associated diseases in vivo, human-to-mouse xenotransplantation models for human blood and blood-forming cells and organs have been developed over the past three decades. We here review the fundamental requirements and the remarkable progress made over the past few years in improving these systems, the current major achievements reached by use of these models, and the future challenges to more closely model and study human health and disease and to achieve predictive preclinical testing of both prevention measures and potential new therapies.