Hepatic stellate cells in liver development, regeneration, and cancer.

Publication Type:

Review

Source:

The Journal of clinical investigation, Volume 123, Issue 5, p.1902-10 (2013)

Keywords:

Animalsdigestive disease, digestive deseases Carcinoma, Hepatocellulardigestive disease, digestive deseases Cell Differentiationdigestive disease, digestive deseases Endothelial Cellsdigestive disease, digestive deseases Fibrosisdigestive disease, digestive deseases Hepatic Stellate Cellsdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Liverdigestive disease, digestive deseases Liver Diseasesdigestive disease, digestive deseases Liver Failure, Acutedigestive disease, digestive deseases Liver Neoplasmsdigestive disease, digestive deseases Liver Regenerationdigestive disease, digestive deseases Micedigestive disease, digestive deseases Microscopy, Phase-Contrast

Abstract:

Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver physiology and fibrogenesis. They are located in the space of Disse and maintain close interactions with sinusoidal endothelial cells and hepatic epithelial cells. It is becoming increasingly clear that hepatic stellate cells have a profound impact on the differentiation, proliferation, and morphogenesis of other hepatic cell types during liver development and regeneration. In this Review, we summarize and evaluate the recent advances in our understanding of the formation and characteristics of hepatic stellate cells, as well as their function in liver development, regeneration, and cancer. We also discuss how improved knowledge of these processes offers new perspectives for the treatment of patients with liver diseases.