The hematopoietic stem cell niche--home for friend and foe?

Publication Type:

Review

Source:

Cytometry. Part B, Clinical cytometry, Volume 84, Issue 1, p.7-20 (2013)

Keywords:

Adipocytesdigestive disease, digestive deseases Bone Marrow Cellsdigestive disease, digestive deseases Cell Differentiationdigestive disease, digestive deseases Cytokinesdigestive disease, digestive deseases Extracellular Matrixdigestive disease, digestive deseases Hematologic Neoplasmsdigestive disease, digestive deseases Hematopoietic Stem Cellsdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Macrophagesdigestive disease, digestive deseases Mesenchymal Stromal Cellsdigestive disease, digestive deseases Stem Cell Factordigestive disease, digestive deseases Stem Cell Niche

Abstract:

The hematopoietic stem cell (HSC) niche is involved in the maintainance and regulation of quiescence, self-renewal and differentiation of hematopoietic stem cells and the fate of their progeny in mammals dealing with the daily stresses to the hematopoietic system. From the discovery that perturbations of the HSC niche can lead to hematopoietic disorders, we have now arrived at the prospect that the HSC niche may play a role in hematological malignancies and that this HSC niche may be a target for therapy. This review attempts to capture the discoveries of the last few years regarding the normal and malignant hematopoietic stem cell niche and possible ways to target this niche.