Gene regulatory networks governing pancreas development.

Publication Type:

Review

Source:

Developmental cell, Volume 25, Issue 1, p.5-13 (2013)

Keywords:

Acinar Cellsdigestive disease, digestive deseases Animalsdigestive disease, digestive deseases Basic Helix-Loop-Helix Transcription Factorsdigestive disease, digestive deseases Cell Dedifferentiationdigestive disease, digestive deseases Cell Differentiationdigestive disease, digestive deseases Computational Biologydigestive disease, digestive deseases Data Miningdigestive disease, digestive deseases Diabetes Mellitusdigestive disease, digestive deseases Gene Regulatory Networksdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Insulin-Secreting Cellsdigestive disease, digestive deseases Nerve Tissue Proteinsdigestive disease, digestive deseases Nucleotide Motifsdigestive disease, digestive deseases Pancreasdigestive disease, digestive deseases Stem Cells

Abstract:

Elucidation of cellular and gene regulatory networks (GRNs) governing organ development will accelerate progress toward tissue replacement. Here, we have compiled reference GRNs underlying pancreas development from data mining that integrates multiple approaches, including mutant analysis, lineage tracing, cell purification, gene expression and enhancer analysis, and biochemical studies of gene regulation. Using established computational tools, we integrated and represented these networks in frameworks that should enhance understanding of the surging output of genomic-scale genetic and epigenetic studies of pancreas development and diseases such as diabetes and pancreatic cancer. We envision similar approaches would be useful for understanding the development of other organs.