Gastric acid, calcium absorption, and their impact on bone health.

Publication Type:

Journal Article

Source:

Physiological reviews, Volume 93, Issue 1, p.189-268 (2013)

Keywords:

Animalsdigestive disease, digestive deseases Antacidsdigestive disease, digestive deseases Bone and Bonesdigestive disease, digestive deseases Bone Diseases, Metabolicdigestive disease, digestive deseases Calcitonindigestive disease, digestive deseases Calciumdigestive disease, digestive deseases Gastric Aciddigestive disease, digestive deseases Gastric Mucosadigestive disease, digestive deseases Histamine H2 Antagonistsdigestive disease, digestive deseases Homeostasisdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Hydrogen-Ion Concentrationdigestive disease, digestive deseases Intestinal Absorptiondigestive disease, digestive deseases Intestinesdigestive disease, digestive deseases Parathyroid Hormonedigestive disease, digestive deseases Proton Pump Inhibitorsdigestive disease, digestive deseases Receptors, Calcium-Sensingdigestive disease, digestive deseases Signal Transductiondigestive disease, digestive deseases Vitamin D

Abstract:

Calcium balance is essential for a multitude of physiological processes, ranging from cell signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a major factor for maintaining systemic calcium homeostasis. Recent observations indicate that a reduction of gastric acidity may impair effective calcium uptake through the intestine. This article reviews the physiology of gastric acid secretion, intestinal calcium absorption, and their respective neuroendocrine regulation and explores the physiological basis of a potential link between these individual systems.