Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver.

Publication Type:

Journal Article

Source:

Molecular and cellular endocrinology, Volume 366, Issue 2, p.152-62 (2013)

Keywords:

Adiponectindigestive disease, digestive deseases AMP-Activated Protein Kinasesdigestive disease, digestive deseases Animalsdigestive disease, digestive deseases Endocrine Systemdigestive disease, digestive deseases Energy Metabolismdigestive disease, digestive deseases Gene Expression Regulationdigestive disease, digestive deseases Ghrelindigestive disease, digestive deseases Glucagondigestive disease, digestive deseases Glucosedigestive disease, digestive deseases Humansdigestive disease, digestive deseases Insulindigestive disease, digestive deseases Leptindigestive disease, digestive deseases Liverdigestive disease, digestive deseases Micedigestive disease, digestive deseases Resistindigestive disease, digestive deseases Signal Transduction

Abstract:

This review summarizes the emerging role of AMP-activated protein kinase (AMPK) in mediating endocrine regulation of metabolic fluxes in the liver. There are a number of hormones which, when acting on the liver, alter AMPK activation. Here we describe those hormones associated with activation and de-activation of AMPK and the potential mechanisms for changes in AMPK activation state. The actions of these hormones, in many cases, are consistent with downstream effects of AMPK signaling thus strengthening the circumstantial case for AMPK-mediated hormone action. In recent years, genetic mouse models have also been used in an attempt to establish the role of AMPK in hormone-stimulated metabolism in the liver. Few experiments have, however, firmly established a causal relationship between hormone action at the liver and AMPK signaling.