Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions.

Publication Type:

Journal Article


Cellular and molecular life sciences : CMLS, Volume 70, Issue 2, p.223-37 (2013)


Animalsdigestive disease, digestive deseases Dual Specificity Phosphatase 1digestive disease, digestive deseases Humansdigestive disease, digestive deseases Macrophagesdigestive disease, digestive deseases Micedigestive disease, digestive deseases Mice, Knockoutdigestive disease, digestive deseases Mitogen-Activated Protein Kinasesdigestive disease, digestive deseases Neoplasmsdigestive disease, digestive deseases Phosphorylationdigestive disease, digestive deseases Signal Transduction


The balance of protein phosphorylation is achieved through the actions of a family of protein serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The propagation of MAPK signals is attenuated through the actions of the MAPK phosphatases (MKPs). The MKPs specifically inactivate the MAPKs by direct dephosphorylation. The archetypal MKP family member, MKP-1 has garnered much of the attention amongst its ten other MKP family members. Initially viewed to play a redundant role in the control of MAPK signaling, it is now clear that MKP-1 exerts profound regulatory functions on the immune, metabolic, musculoskeletal and nervous systems. This review focuses on the physiological functions of MKP-1 that have been revealed using mouse genetic approaches. The implications from studies using MKP-1-deficient mice to uncover the role of MKP-1 in disease will be discussed.