University of Chicago Digestive Diseases Research Core Center

Research Focus

At the University of Chicago DDRCC, we are at the forefront of research in three fields, led by well-known investigators: Dr. Bana Jabri in Celiac disease, Dr. Cathryn Nagler in food allergy and Dr. Eugene B. Chang in inflammatory bowel diseases. The central hypothesis of the collective group is that IBD and related inflammatory diseases of the bowel arise from a confluence of host, microbial, immunological, and environmental factors. Within the field of IBD, the program has 4 major interrelated research themes that focus on the etiopathogenesis of IBD: (1) host immune/tissue responses, (2) the gut microbiome, (3) host genetics and gene function, and (4) environmental modifiers.