Michigan Gastrointestinal Peptide Research Center

Research Focus

Over the last 5 years, the Center has grown from 55 to 81 primary investigators. They have mutual interests in the Center research activities and contributed substantially to the Center's research base by participating in core laboratories, collaborative efforts with other Center investigators, and serving on Center committees. Although the Center investigators have diverse research goals and objectives they share a common thread interest on the biochemistry and physiology of the neurohormonal mediators of communication between different cells or organs of the body. Some investigators focus on basic molecular research while others concentrate on more integrated systems. Some work primarily on gastrointestinal research problems with only a peripheral interest in peptide hormones, while others work with gut peptides in non-gastroenteric organs. Over the course of the last 20 years, the Center has united its investigators together in a collaborative effort that has broadened the horizons of the individual laboratories and moreover, widened interest in digestive disease related research. The specific research interests of the Center investigators can be grouped in the following arenas:

  • Transgenics and Gene Expression Profiling
  • Signal Transduction
  • Pancreatic secretions and growth in health and disease
  • Physiology and pathophysiology of gastric parietal cell
  • Vagal physiology and digestive functions
  • GI Motility Studies
  • Neural peptides and regulation of visceral pain
  • Human studies