Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG)

Core Facilities

The Center is composed of three cores.


The Clinical Core has two primary objectives:

Objective 1: To enhance existing individual GI-related biobanks operating within the Clinical Core umbrella and develop future repositories.
We facilitate the collection, management, and annotation of GI biospecimens that can enhance the translational research within each of the 3 C-SiG Disease Focus Areas (enteric neurosciences, liver pathobiology, and inflammation/cell transformation). Emphasis is placed on expanding existing and developing new human frozen digestive disease-related tissue collections relevant to the needs of the members as indicated by previous tissue requests, annual membership surveys, and discussions with the existing GI-biobanks.

Objective 2: Facilitating C-SiG member access to GI tissues
Translation of basic research discoveries requires validation of biomedical markers in human tissues. The Clinical Core is designed to link C-SiG investigators with clinically, epidemiologically, and molecularly annotated biospecimens for basic research projects and clinical translation of basic research discoveries. The Clinical Core provides a user friendly connection for researchers to access biospecimens collected by multiple IRB approved tissue collections from the entire luminal GI tract, pancreas, and hepatobiliary organ systems.

  • Centralized access to 18 participating GI biobanks and institutional biospecimen resources
  • Institutional Review Board (IRB) protocol development and modification support
  • Identification of biospecimens meeting your specific research criteria
  • Pathologist review of tissues
  • Biospecimen processing request form support
  • Access to the Clinical Core database that serves as an electronic repository of clinical, epidemiological and molecular data
  • De-identified, phenotypic data
  • Standardized epidemiological questionnaire for GI biobanks
  • Expedited implementation of barcoding technology and database software for biospecimen inventory management
  • Tissue microarray (TMA) support services
  • Stool collection kits and -80 degree Celsius sample storage for human microbiome-related research

Visit the Core