Marion Bessin Liver Research Center

Investigators


NAME TITLE RESEARCH INTERESTS

*Provisional Investigator

DEPARTMENT OF MEDICINE

Allan W. Wolkoff Professor Cell Biology of the Liver, Organic
(and Anatomy & Structural Anion Transport
Biology)

David A. Shafritz Professor Liver Cell Engineering, Growth
(and Cell Biology; Control, and Liver Repopulation
Pathology)

Charles E. Rogler Professor microRNA Biology and Human
(and Microbiology & Disease
Immunology; Genetics)

Jayanta Roy-Chowdhury Professor Bilirubin Metabolism, Genetic
(and Genetics) Diseases, Gene Therapy

Namita Roy-Chowdhury Professor Bilirubin Metabolism,
(and Genetics) Glucuronidation, Gene Therapy

Sanjeev Gupta Professor Hepatocyte Transplantation
(and Pathology) and Gene Therapy

Michael Brownlee Professor Hepatic Carbohydrate Metabolism
(and Pathology)

Rajat Singh Associate Professor Autophagy, Regulation of Lipid
(and Molec. Pharmacol.) Metabolism; Energy Homeostasis

Fajun Yang Associate Professor Molecular Mechanisms of Gene
(and Developmental Expression in Nutrient
and Molecular Biology) Homeostasis

Leslie E. Rogler Assistant Professor Liver Development and Gene
Regulation

Carolina I. Eliscovich Assistant Professor Regulation in Gene Expression
(and Anatomy & in Liver Tissues
Structural Biology)

DEPARTMENT OF ANATOMY AND STRUCTURAL BIOLOGY

Robert H. Singer Professor Single mRNA Molecules from Cradle
(Neuroscience and to Grave; Trafficking Microscopy
Cell Biology)

U. Thomas Meier Professor Nuclear-Cytoplasmic Transport

Arne Gennerich Associate Professor Molecular Motors for Cellular
Trafficking

DEPARTMENT OF BIOCHEMISTRY

Maureen J. Charron Professor Glucose Metabolism and Glucose
(and OB/Gyn & Transporters
Women’s Health;
Medicine)

Ian M. Willis Professor Transcription of Small RNAs by RNA
(and Systems Polymerase III
& Computational
Biology)

Matthew Levy Associate Professor Lipid Metabolism and Design
of Novel Therapeutics

DEPARTMENT OF CELL BIOLOGY

Pamela M. Stanley Professor Carbohydrates and Cell
Membranes

Arthur I. Skoultchi Professor Regulation of Gene Expression
and Differentiation

Wenjun Guo Assistant Professor Stem cell biology

DEPARTMENT OF DEVELOPMENTAL AND MOLECULAR BIOLOGY

Ana Maria Cuervo Professor Autophagy and Aging
(and Anatomy & Structural
Biology; Medicine)

Duncan W. Wilson Professor Membrane Function and
Endocytosis

Liang Zhu Professor Regulation of the Cell Cycle
(and Medicine)

Anne Müsch Professor Membrane Biology and Function

Andreas Jenny Associate Professor Fz-Adapter Protein Dsh Regulated
(and Genetics) by Phosphorylation, Autophagy
DEPARTMENT OF GENETICS

Nicholas E. Baker Professor Regulation of Cell Proliferation and
(and Developmental & Organ Development in Drosophila
Molecular Biology)

John M. Greally Professor Epigenomics, Gene Regulation,
(and Medicine/Hematology; HCV-Mediated Oncogenesis
Pediatrics)

DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

Kami Kim Professor Malaria
(Infectious Diseases)

DEPARTMENT OF MOLECULAR PHARMACOLOGY

Jonathan Backer Professor Signal Transduction

DEPARTMENT OF NEUROSCIENCE

David C. Spray Professor Gap Junction Function
(and Medicine/Cardiology)

DEPARTMENT OF PEDIATRICS

Robert D. Burk Professor Molecular Genetics and Viral-
(and Microbiology & Mediated Oncogenesis,
Immunology; OB/Gyn Microbiome and Disease
& Women’s Health;
Epidemiology and
Population Health)

DEPARTMENT OF RADIATION ONCOLOGY

Chandan Guha Professor Radiation Liver Injury and Cell
(and Pathology) Transplantation

*Patrik Asp Instructor
(Surgery)

Marion Bessin Liver Research Center

SCIENTIFIC ADVISORY COMMITTEE:

Members:
Allan W. Wolkoff, M.D., Director, Albert Einstein College of Medicine
David A. Shafritz, M.D., Associate Director, Albert Einstein College of Medicine

Irwin M. Arias, National Institutes of Health
Jorge A. Bezerra, Cincinnati Children’s Hospital Medical Center
David E. Cohen, New York-Presbyterian/Weill Cornell Medical Center
Mark A. McNiven, Mayo Clinic
Enrique J. Rodriquez-Boulan, Weill-Cornell Medical College
Harry Shamoon, Albert Einstein College of Medicine
Satdarshan P. Singh Monga, University of Pittsburgh School of Medicine
Snorri S. Thorgeirsson, National Institutes of Health

  
EXECUTIVE COMMITTEE: 

Members:

Ana Maria Cuervo, M.D., Ph.D.
Chandan Guha, M.B.B.S., Ph.D.
Sanjeev Gupta, M.D.
Charles E. Rogler, Ph.D.
Jayanta Roy-Chowdhury, M.D.

Clinical Component
The Division of Hepatology was recombined with the Division of Gastroenterology to form the Division of Gastroenterology and Liver Diseases at Albert Einstein College of Medicine and Montefiore Medical Center, with Dr. Allan Wolkoff as the Division Chief of this unified service.
Within this Division is the Comprehensive Liver Program that includes specialists in hepatology, oncology, surgery, radiology, psychiatry, pediatric gastroenterology, and family medicine. This change in leadership and reorganization of the clinical services facilitates a new focus on translational research involving clinicians, epidemiologists, biostatisticians, and laboratory scientists to leverage the burden of liver disease in the Bronx, creating opportunities for innovative collaborative research. In addition, cutting-edge treatments for liver disease are available to patients, including advanced clinical trials, novel therapeutic approaches to complex problems, and liver transplantation. This clinical program now works closely with the LRC to bring new fundamental findings and research advances to the study and treatment of human liver diseases.
Services available in the clinical component include:
1. a liver tissue and blood biorepository with an integrated informatics system that bridges the gap between inventory tracking, clinical and pathology annotation and use of this information for cohort extraction and studies on human tissues
2. biostatistical support for the design and interpretation of patient-based studies by LRC investigators
3. access to expertise and technology in epidemiology for design, implementation, quality control, and interpretation of epidemiologic studies
Availability of these new services has resulted in integration of translational research into the LRC. Use of the existing LRC Cores facilitated the development of epidemiological and clinical studies on subjects at risk for liver disease. In addition to ongoing epidemiological projects, a number of new initiatives provide a bridge between more basic liver-related studies and those that would be directly related to patients and patient-based materials. In large part, these projects stem from outreach programs to bring basic liver researchers together with clinical hepatologists and hepatobiliary surgeons.
In addition, the LRC has a close working relationship with the Institute for Clinical and Translational Research (ICTR) at Einstein and Montefiore. The ICTR provides access to the following:
• two Clinical Research Center units
• Biomarker Analytic Research Core
• Biorepository
• Clinical Trials & Regulatory Support Office
• Biostatistics, Epidemiology & Research Design Core
• Community Engagement Consultation Core
• Research Informatics Core
• Project Acceleration Resource
The LRC works closely with the ICTR and has full access to all of its services, providing a milieu conducive to cooperative and collaborative translational investigation.

Members of the Clinical Component

Name
Academic Rank
Department
Research Field

John F. Reinus, MD
Professor
Medicine/Hepatology
HCV; portal hypertension

Jonathan M. Schwartz, MD
Associate Professor
Medicine/Hepatology
HCC

Samuel H. Sigal, MD
Associate Professor
Medicine/Hepatology
Liver failure

Alain H. Litwin, MD
Professor
Medicine/Psychiatry
HCV; treatment outcomes

Harmit S. Kalia, DO
Assistant Professor
Medicine/Hepatology
NAFLD

Kathryn E. Tanaka, MD
Associate Professor
Pathology
Hepatic inflammation

Milan Kinkhabwala, MD
Professor
Surgery/ Transplantation
HCC; liver failure

Steven K. Libutti, MD
Professor
Surgery/Genetics
Tumor neovascular formation

Sarah Bellemare, MD
Assistant Professor
Surgery/ Transplantation
HCC; liver failure

Diego Camacho, MD
Assistant Professor
Surgery/Bariatrics
NAFLD

Nadia Ovchinsky, MD
Assistant Professor
Pediatrics/Hepatology
Pediatric liver disease; Lysosome disorders, NAFLD in children

Howard Strickler, MD
Professor
Epidemiology & Population Health
Epidemiology of HCV

Mimi Kim, ScD
Professor
Epidemiology & Population Health
Biostatistics and clinical study design