Center for the Study of Inflammatory Bowel Disease, MGH

Core Facilities

The Biomedical Core program has been a central feature of the CSIBD since its inception. These core resources have been developed to accomplish two goals: first, to support the research activities of the center investigators that increase the understanding of IBD, and second, to stimulate new collaborations and interactions. The biomedical cores have been greatly successful in meeting both of these goals. The first goal has been met through both service and educational activities of the individual cores. As a mark of achieving the second goal, the use of these biomedical cores has led to projects that would not have been undertaken if the cores had not been available. We are continually working to maintain this high level of research support and investigator interaction. The Center has Five cores:


GENETIC ANIMAL MODELS CORE

The Genetic Animal Models Core was initially developed to facilitate the use of informative animal models of chronic colitis. Murine models of intestinal inflammation arising from a number of genetic manipulations offer the most direct means to approach the underlying hypothesis of the CSIBD, i.e. characterization of the effects of genetic factors in altering mucosal barrier function and immune responses that lead to chronic inflammation. These models also allow the opportunity to define the importance of interaction among different genetic loci and the impact of environmental factors on phenotypic expression of IBD. As a result of these developments, this core places a major emphasis on these valuable research tools, providing economical access to these models by CSIBD investigators and promoting further characterization of these models. Learn More...

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