Computational genetic discoveries that could improve perioperative medicine.

Publication Type:

Journal Article


Current opinion in anaesthesiology, Volume 25, Issue 4, p.428-33 (2012)


PURPOSE OF REVIEW: The review examines the rationale and translational utility of computational genetic studies using murine models of biomedical traits.

RECENT FINDINGS: Computational genetic mapping studies have identified the genetic basis for biomedical trait differences in 16 different murine models, including several that are of importance to perioperative medicine.

SUMMARY: The results have generated new treatments for alleviating incisional pain and narcotic drug withdrawal symptoms, which are now in clinical trials. A recent study identified allelic differences affecting chronic pain responses in mice and humans, which may enable a new 'personalized' approach to treating chronic pain.