Bacterial subversion of host innate immune pathways.

Publication Type:

Review

Source:

Science (New York, N.Y.), Volume 340, Issue 6133, p.697-701 (2013)

Keywords:

Autophagydigestive disease, digestive deseases Bacteriadigestive disease, digestive deseases Bacterial Infectionsdigestive disease, digestive deseases Bacterial Secretion Systemsdigestive disease, digestive deseases Escherichia coli Proteinsdigestive disease, digestive deseases Host-Pathogen Interactionsdigestive disease, digestive deseases Humansdigestive disease, digestive deseases Immunity, Innatedigestive disease, digestive deseases Inflammationdigestive disease, digestive deseases Phagocytosisdigestive disease, digestive deseases Transcription, Genetic

Abstract:

The pathogenesis of infection is a continuously evolving battle between the human host and the infecting microbe. The past decade has brought a burst of insights into the molecular mechanisms of innate immune responses to bacterial pathogens. In parallel, multiple specific mechanisms by which microorganisms subvert these host responses have been uncovered. This Review highlights recently characterized mechanisms by which bacterial pathogens avoid killing by innate host responses, including autophagy pathways and a proinflammatory cytokine transcriptional response, and by the manipulation of vesicular trafficking to avoid the toxicity of lysosomal enzymes.