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2012
Intraductal Administration of a Polymeric Nanoparticle Formulation of Curcumin (NanoCurc) Significantly Attenuates Incidence of Mammary Tumors in a Rodent Chemical Carcinogenesis Model Implications for breast cancer chemoprevention in at-risk populations.
Chun YS
,
Bisht S
,
Chenna V
,
Pramanik D
,
Yoshida T
,
Hong S-M
,
de Wilde RF
,
Zhang Z
,
Huso D
,
Zhao M
,
Rudek M
,
Stearns V
,
Maitra A
,
Sukumar S
Carcinogenesis
, 2012 Jul 25
, (2012)
PubMed
Sialofucosylated Podocalyxin is a Functional E- and L-Selectin Ligand Expressed by Metastatic Pancreatic Cancer Cells.
Dallas MR
,
Chen S-H
,
Streppel MM
,
Sharma S
,
Maitra A
,
Konstantopoulos K
American journal of physiology. Cell physiology
, 2012 Jul 18
, (2012)
PubMed
Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma.
Yamanaka S
,
Campbell NR
,
An F
,
Kuo SC
,
Potter JJ
,
Mezey E
,
Maitra A
,
Selaru FM
Cell cycle (Georgetown, Tex.)
, 2012 Jul 15
, Volume 11
, Issue 14
, p.2729-38
, (2012)
PubMed
Genetically defined subsets of human pancreatic cancer demonstrate unique in vitro chemosensitivity.
Cui Y
,
Brosnan JA
,
Blackford AL
,
Sur S
,
Hruban RH
,
Kinzler KW
,
Vogelstein B
,
Maitra A
,
Diaz LA
,
Iacobuzio-Donahue CA
,
Eshleman JR
Clinical cancer research : an official journal of the American Association for Cancer Research
, 2012 Jul 2
, (2012)
PubMed
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors.
de Wilde RF
,
Heaphy CM
,
Maitra A
,
Meeker AK
,
Edil BH
,
Wolfgang CL
,
Ellison TA
,
Schulick RD
,
Molenaar QI
,
Valk GD
,
Vriens MR
,
Borel Rinkes IHM
,
Offerhaus JGA
,
Hruban RH
,
Matsukuma KE
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
, 2012 Jul
, Volume 25
, Issue 7
, p.1033-9
, (2012)
PubMed
A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy.
Pramanik D
,
Campbell NR
,
Das S
,
Gupta S
,
Chenna V
,
Bisht S
,
Sysa-Shah P
,
Bedja D
,
Karikari C
,
Steenbergen C
,
Gabrielson KL
,
Maitra A
,
Maitra A
Oncotarget
, 2012 Jul
, Volume 3
, Issue 6
, p.640-50
, (2012)
PubMed
Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.
Streppel MM
,
Vincent A
,
Mukherjee R
,
Campbell NR
,
Chen S-H
,
Konstantopoulos K
,
Goggins MG
,
Van Seuningen I
,
Maitra A
,
Montgomery EA
Human pathology
, 2012 Apr 26
, (2012)
PubMed
Well-differentiated pancreatic neuroendocrine tumors: from genetics to therapy.
de Wilde RF
,
Edil BH
,
Hruban RH
,
Maitra A
Nature reviews. Gastroenterology & hepatology
, 2012 Apr
, Volume 9
, Issue 4
, p.199-208
, (2012)
PubMed
Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas.
Dal Molin M
,
Hong S-M
,
Hebbar S
,
Sharma R
,
Scrimieri F
,
de Wilde RF
,
Mayo SC
,
Goggins M
,
Wolfgang CL
,
Schulick RD
,
Lin M-T
,
Eshleman JR
,
Hruban RH
,
Maitra A
,
Matthaei H
Human pathology
, 2012 Apr
, Volume 43
, Issue 4
, p.585-91
, (2012)
PubMed
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.
Kanda M
,
Matthaei H
,
Wu J
,
Hong S-M
,
Yu J
,
Borges M
,
Hruban RH
,
Maitra A
,
Kinzler K
,
Vogelstein B
,
Goggins M
Gastroenterology
, 2012 Apr
, Volume 142
, Issue 4
, p.730-733.e9
, (2012)
PubMed
Polymeric Nanoparticle-Encapsulated Hedgehog Pathway Inhibitor HPI-1 (NanoHHI) Inhibits Systemic Metastases in an Orthotopic Model of Human Hepatocellular Carcinoma.
Xu Y
,
Chenna V
,
Hu C
,
Sun H-X
,
Khan M
,
Bai H
,
Yang X-R
,
Zhu Q-F
,
Sun Y-F
,
Maitra A
,
Fan J
,
Anders RA
Clinical cancer research : an official journal of the American Association for Cancer Research
, 2012 Mar 1
, Volume 18
, Issue 5
, p.1291-302
, (2012)
PubMed
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors.
Yachida S
,
Vakiani E
,
White CM
,
Zhong Y
,
Saunders T
,
Morgan R
,
de Wilde RF
,
Maitra A
,
Hicks J
,
Demarzo AM
,
Shi C
,
Sharma R
,
Laheru D
,
Edil BH
,
Wolfgang CL
, et al.
The American journal of surgical pathology
, 2012 Feb
, Volume 36
, Issue 2
, p.173-84
, (2012)
PubMed
EMT and dissemination precede pancreatic tumor formation.
Rhim AD
,
Mirek ET
,
Aiello NM
,
Maitra A
,
Bailey JM
,
McAllister F
,
Reichert M
,
Beatty GL
,
Rustgi AK
,
Vonderheide RH
,
Leach SD
,
Stanger BZ
Cell
, 2012 Jan 20
, Volume 148
, Issue 1-2
, p.349-61
, (2012)
PubMed
Molecular determinants of retinoic acid sensitivity in pancreatic cancer.
Gupta S
,
Pramanik D
,
Mukherjee R
,
Campbell NR
,
Elumalai S
,
de Wilde RF
,
Hong S-M
,
Goggins MG
,
De Jesus-Acosta A
,
Laheru D
,
Maitra A
Clinical cancer research : an official journal of the American Association for Cancer Research
, 2012 Jan 1
, Volume 18
, Issue 1
, p.280-9
, (2012)
PubMed
Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.
Jones S
,
Li M
,
Parsons WD
,
Zhang X
,
Wesseling J
,
Kristel P
,
Schmidt MK
,
Markowitz S
,
Yan H
,
Bigner D
,
Hruban RH
,
Eshleman JR
,
Iacobuzio-Donahue CA
,
Goggins M
,
Maitra A
, et al.
Human mutation
, 2012 Jan
, Volume 33
, Issue 1
, p.100-3
, (2012)
PubMed
A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.
Chenna V
,
Hu C
,
Pramanik D
,
Aftab BT
,
Karikari C
,
Campbell NR
,
Hong S-M
,
Zhao M
,
Rudek MA
,
Khan SR
,
Rudin CM
,
Maitra A
Molecular cancer therapeutics
, 2012 Jan
, Volume 11
, Issue 1
, p.165-73
, (2012)
PubMed
2011
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.
Wu J
,
Jiao Y
,
Dal Molin M
,
Maitra A
,
de Wilde RF
,
Wood LD
,
Eshleman JR
,
Goggins MG
,
Wolfgang CL
,
Canto MI
,
Schulick RD
,
Edil BH
,
Choti MA
,
Adsay V
,
Klimstra DS
, et al.
Proceedings of the National Academy of Sciences of the United States of America
, 2011 Dec 27
, Volume 108
, Issue 52
, p.21188-93
, (2011)
PubMed
Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer.
Matthaei H
,
Hong S-M
,
Mayo SC
,
Dal Molin M
,
Olino K
,
Venkat R
,
Goggins M
,
Herman JM
,
Edil BH
,
Wolfgang CL
,
Cameron JL
,
Schulick RD
,
Maitra A
,
Hruban RH
Annals of surgical oncology
, 2011 Nov
, Volume 18
, Issue 12
, p.3493-9
, (2011)
PubMed
Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models.
Feldmann G
,
Mishra A
,
Bisht S
,
Karikari C
,
Garrido-Laguna I
,
Rasheed Z
,
Ottenhof NA
,
Dadon T
,
Alvarez H
,
Fendrich V
,
Rajeshkumar NV
,
Matsui W
,
Brossart P
,
Hidalgo M
,
Bannerji R
, et al.
Cancer biology & therapy
, 2011 Oct 1
, Volume 12
, Issue 7
, p.598-609
, (2011)
PubMed
Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas.
Fendrich V
,
Oh E
,
Bang S
,
Karikari C
,
Ottenhof N
,
Bisht S
,
Lauth M
,
Brossart P
,
Katsanis N
,
Maitra A
,
Feldmann G
Neoplasia (New York, N.Y.)
, 2011 Oct
, Volume 13
, Issue 10
, p.923-30
, (2011)
PubMed
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.
Heaphy CM
,
Subhawong AP
,
Hong S-M
,
Goggins MG
,
Montgomery EA
,
Gabrielson E
,
Netto GJ
,
Epstein JI
,
Lotan TL
,
Westra WH
,
Shih I-M
,
Iacobuzio-Donahue CA
,
Maitra A
,
Li QK
,
Eberhart CG
, et al.
The American journal of pathology
, 2011 Oct
, Volume 179
, Issue 4
, p.1608-15
, (2011)
PubMed
Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer.
Garrido-Laguna I
,
Uson M
,
Rajeshkumar NV
,
Tan AC
,
de Oliveira E
,
Karikari C
,
Villaroel MC
,
Salomon A
,
Taylor G
,
Sharma R
,
Hruban RH
,
Maitra A
,
Laheru D
,
Rubio-Viqueira B
,
Jimeno A
, et al.
Clinical cancer research : an official journal of the American Association for Cancer Research
, 2011 Sep 1
, Volume 17
, Issue 17
, p.5793-800
, (2011)
PubMed
A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation.
Bisht S
,
Khan MA
,
Bekhit M
,
Bai H
,
Cornish T
,
Mizuma M
,
Rudek MA
,
Zhao M
,
Maitra A
,
Ray B
,
Lahiri D
,
Maitra A
,
Anders RA
Laboratory investigation; a journal of technical methods and pathology
, 2011 Sep
, Volume 91
, Issue 9
, p.1383-95
, (2011)
PubMed
Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice.
Pramanik D
,
Campbell NR
,
Karikari C
,
Chivukula R
,
Kent OA
,
Mendell JT
,
Maitra A
Molecular cancer therapeutics
, 2011 Aug
, Volume 10
, Issue 8
, p.1470-80
, (2011)
PubMed
Altered telomeres in tumors with ATRX and DAXX mutations.
Heaphy CM
,
de Wilde RF
,
Jiao Y
,
Klein AP
,
Edil BH
,
Shi C
,
Bettegowda C
,
Rodriguez FJ
,
Eberhart CG
,
Hebbar S
,
Offerhaus JG
,
McLendon R
,
Rasheed AB
,
He Y
,
Yan H
, et al.
Science (New York, N.Y.)
, 2011 Jul 22
, Volume 333
, Issue 6041
, p.425
, (2011)
PubMed
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